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a new dietary supplement that i ran across on the john hopkins university web site.
Celadrin® is an all natural proprietary ingredient, that has been clinically proven to reduce pain and rapidly promote joint health, improving flexibility and mobility. Clinically studied at various times in Vivo, it has been published twice in the prestigious Journal of Rheumatology.
Available for oral and topical applications, Celadrin's beneficial effects have been proven superior in results to Glucosamine, Chondroitin, MSM, SAMe and other arthritic medications.
i also have been checking out clinical trial for osteoarthritis of the knee. i found one in tampa that involes doing iv treatments, the study will last 6 months and is a double-blind study so i won't know if i receive RN624 or a placebo.
the right knee has been doing alot worse lately and i am not about to give up!
anyone ever use celadrin? or parcipate in a clinical trial?
last edited: 3/13/07 8:59:09 PM”
“It sounds great, cyndeee. Have you ordered some, yet?”
“Cyndeee, Never have tried it but I'm a firm believer in help from pharmaceuticals when it comes to arthritis. I miss my bextra terribly. If you can find a drug that helps you it's a wonderful thing. It sure does hurt when they take it off the market though!
If you try Celedrin let us know how it works for you please.”
“I'd like to know, too, please.”
“just started on the pills yesterday but i haven't found the cream yet. i'll keep yall posted.”
“I just realized this isn't a prescription! Next time I have a flare up I'll definitely give this a try.
Keep us posted Cyndeee.”
“Thanks! I'll have to let my dad know about this. He broke his back way back then and never really got proper care for it. Now he's so eaten up with arthritis and scar tissue they won't even operate to try to fix anything. He was taking something a few years ago that he said really helped, but it was taken off the market because of lawsuits or something.”
“Same stuff I was in love with, Bextra or Celebrex. It was good.”
“celebrex, that was it.
Now I believe the drug of choice is vicodin.”
“sass where do you have the arthritis? One of my friends in the weight room has it really bad in the knees, and shoulders (can you guess he was a football player?) he has some exercises he does that seem to help.”
“Xl, I have a weird form of Arthritis called Pseudogout (calcium pyrophosphate deposition disease). Right now it's not anywhere. Last year it was in my left knee. The year before it was in my left big toe joint. It pops up occasionally and stays for about 4-8 months (so far, hope never longer or even better never again). The easy way to describe it is an excess of calcium crystals in the synovial fluid of the joint. It makes the entire joint swell to about twice it's size and it hurts like hell. Then, it goes away as quickly as it came. There's nothing to do for it but wait and ice,and take whatever drugs I can to alleviate the pain. Bextra was my friend. I have a wonderful doctor who graciously gave me three boxes of samples before it was officially pulled. They're all gone now but I have fond memories of sweet relief in pill form.
Unfortunately there is nothing I can do except stop taking CA supplements, which is kinda sucky because every single older woman in my family has osteoporosis. So, high impact sports is my only option for bone density increase. There's nothing specific to help the disease, diet or exercise wise.
last edited: 3/14/07 2:16:20 PM”
“I'll add my voice to those asking to let us know how it works.”
“From the website:
Q - What is Celadrin®?
A – Celadrin® is one of the newest, most effective natural anti-inflammatory compounds that safely promotes flexibility and healthy joint function. Clinical studies have reported significant results without any side effects.
Q – What is Celadrin® made from?
A – Celadrin® is made from a patented complex blend of special esterified fatty acids, derived from bovine tallow oil.
Q – Is Celadrin® Safe?
A – Celadrin® is a very safe mix of fatty acids with no known or reported negative reactions or side effects. The esterification process takes place at extremely high temperatures (over 500 degrees Fahrenheit). Scientific Acute Toxicity and Ames test screening have validated its safety. Over 100 million Celadrin® pills have been distributed to date.
Q – How does Celadrin® work?
A – Celadrin® decreases inflammation and lubricates cell membranes throughout the body, restoring fluids that cushion bones and joints to promote flexibility and mobility. Over time, because of the reduction of inflammation delivered by using Celadrin®, the joints and surrounding tissue have an opportunity to promote healthy joints.
Celadrin® works similar to, but much more dramatically than the essential fatty acids EPA and DHA from fish oils. Celadrin’s complex blend of esterified fatty acids; provide many vital and beneficial effects for the inflammatory responses in the body. Celadrin® induces changes at the cellular level, in the cell membranes which positively affect the responsiveness of the cell membranes. This aids in the reduction of cartilage breakdown in the joints.
Q – Is their any science behind Celadrin®?
A – Celadrin® has been clinically studied at various times with results published in the prestigious Journal of Rheumatology for both oral and topical applications as well as the Journal of Strength and Conditioning Research.
For oral application, Celadrin® was studied using a double-blind, multi-center, placebo-controlled trial (the most scientifically validated type). Sixty-four participants between the ages of 37 to 77 were given Celadrin® capsules and were evaluated at the beginning of the trial, at 30 days and at the end of the 68 day study. Compared to those given a placebo, those who were given Celadrin® had more flexibility, fewer aches, less pain and were able to walk further distances than the placebo group. The study therefore concluded that Celadrin®, when taken orally improved joint and mobility problems.
For topical application of Celadrin® cream, a study was conducted at the University of Connecticut, involving 42 patients with osteoarthritis of the knee. Participants used either Celadrin® or a placebo cream. Patients were evaluated before application of the cream, 30 minutes after, and then again following a 30 day treatment period during which the cream was applied twice a day, morning and evening. The researchers evaluated physical function, postural movement, pain and range of motion. The test included how long it took the patient to get up and go from a chair, stair climbing, endurance, and mobility of the knee. The group receiving Celadrin® had outstanding results with reduced pain and stiffness, improved balance and strength and better mobility. 100% of the patients in the study showed significant benefit compared to the patients on the placebo. Even more exiting was that patients experienced a dramatic improvement in all aspects tested after only 30 minutes of applying the cream with cumulative benefits occurring after 30 days.
An additional study, as an extension of this original study, confirmed earlier research showing improvement in elbow, wrist and knee mobility and significant reduction in pain.
Q – Which is better, Celadrin® cream or Celadrin® pills?
A – Both oral and topical applications were shown to be equally effective in a separate study, where it was proven that the Esterified Fatty Acids (EFAC) found in Celadrin®, could be absorbed by either method (95.1% absorption rate proven through a University of Minnesota labeled study) into the body.
Q – How would you compare Vioxx and other Cox 2 – Inhibitors to Celadrin®?
A - Vioxx works as a Cox-2 inhibitor, which causes numerous side effects - including upper and lower G.I. bleeding amongst other even more serious side effects. The whole class of Cox-2 inhibitors raises doubts about their safety. These drugs were supposed to offer the pain killing features of aspirin without damage to the stomach lining.
When taking Vioxx or other Cox-2s one only receives pain relief for a short period of time. Celadrin® helps relieve the stiffened membrane caused by aging, inflammation and other assaults. Restoration and joint health begins with Celadrin® where it has immediate and cumulative benefits, with no negative side effects. Safety profile of Celadrin® is impeccable. With Celadrin® one is better off tomorrow and the next day than they are today – it just gets better every day as Celadrin® addresses causation not just the symptoms.
Celadrin® works on the cell membrane to allow rapid healing - you don't even need glucosamine to repair cartilage, Celadrin® provides the healing of the joint and surrounding tendons and tissues. One does not need the matrix of the bone to repair a broken arm - but with Celadrin® even that broken arm will be repaired faster - naturally.
In summary, all Cox-2s inherently have serious and numerous side effects - particularly when taken daily.
Q – How does Celadrin® compare to other natural joint health products?
A - Celadrin's beneficial effects have been proven superior in results to Glucosamine, Chondroitin, MSM, SAMe and other natural joint health products.
Celadrin® provides restoration of a wide range of joint health conditions including sports injuries to joints, muscles, tendons and deep tissue.
Q – Can Celadrin® work well in conjunction to taking Glucosamine?
A - The cause of wear on the joint area can be attributable to inflammation as well as insufficient lubrication and cell membrane fluidity. Glucosamine assists in the rebuilding of cartilage & the overall structure of the joint and has shown moderate effects on people with osteoarthritis. Celadrin® provides continuous lubrication and allows the cell membrane to repel inflammatory chemicals. Celadrin® stops the cascade of inflammation and the assaults on the membrane which cause it to stiffen. Celadrin ® empowers glucosamine to perform faster and more efficiently in building joint cartilage as well as accelerating and promoting joint health. The dual action of Celadrin® and glucosamine provide rapid joint cushioning, quickly alleviate inflammation, build cartilage and restore the entire joint area.
Q – Does Celadrin replace fish oils?
A - Although Celadrin is a fatty acid it does not replace the need for Omega 3 fatty acids from fish oils or flaxseed oil. They are complementary and can be taken together; each having their own beneficial action.
Q - Does Celadrin work like Vioxx and Celabrex?
A - No synthetic Cox-2 inhibitors are very specific. In addition to producing inflammatory agents in the body, Cox-2 is required in the manufacture of prostacyclin a very positive prostaglandin. Because Cox-2 uses up this protective prostaglandin this is likely the reason behind its negative effects. Celadrin does not affect prostacylcin and therefor provides a safe, non-toxic anti-inflammatory action.”
“OK, where should I buy Celadrin? I tried two sites from a Google search, but I was unhappy with each. I'm feeling gunshy this morning.
Does anyone have experience buying this stuff?”
“Thanks, Sassafras, but I clicked on several of those places earlier. Then I had to do a search for the product. The searches were unsucessful.”
“I picked up some at Walmart last night. Took my first dose last night and started another today. The recommend double doses the first week, then cut back to single dose. A dose is two caplets, so I'm taking two in the morning and two at night for the first week.
I'll let y'all know if it helps or I turn back into a pumpkin.”
“The t.v just started running a new commercial on Celadrin...a mid-50's guy curling and falls down...then he leaves with his wife saying his leg is bothering him. When they were in the parking lot they looked at each other and smiled. WTF ...I didn't understand the ad... and then the word Celadrin rolled up and the announcer said, "Ask your doctor about it".
I, my family and alot of aquintances thought it was a very bad commercial. We never even bothered to Google it....
So thanks Cyndee.”
“Madison Avenue and logic are mutually exclusive terms.”
“Nowslimmer do you have a Vitacost or Costco? They both sell it. I bet GNC would too, or any other vitamin shop.”
“Tomorrow I will hit some of vitamin and health food stores. Walmart did not have it nor was it in their books. And their web site was one of the places where a search failed. Geobeet, you were lucky. But you don't live in a "hick" town like I do.”
update on celadrin
“i purchased my at a mother earth store in ocala. i'm taking two capsules a day for a total of 1050mgs.
i have been on it for 9 days now and i am no longer limping. i can't believe how well my knees are doing. i will probably cut back on the naproxone tonight. i am no longer limping or hobbling around. my left knee hardly hurts at all. my right knee still has pain but no enough that it causes me to limp. i am still taking the msm, but that is it.
i rode my bike 17miles yesterday and the knee was slightly sore after wards and no worse this morning. i have been on my feet all day and no limp. i can't believe that the doctor doesn't know about this. i was bound and determined not to let his prognoses of, "you're screwed" get me down or give up hope of finding something that would improve my legs. i never in a million years would of thought that i could find relief so fast.
i'm going to prove that SOB doctor he was wrong! i think i'll walk into his office after a backpacking trip, all smelly and dirty and let him know he's screwed cause i'm not coming back to him.
nowslimmer you need to find some of this stuff. i will probably order online next because it was $28.00 at the health food store, but was well worth it.
i came upon this otc medicine by doing a search for new treatments for OA and ended up at the john hopkins university website.
everyone please post your results, it will be very interesting to hear how it works for you. good luck geobeet.
i'm planning on taking a 2-3 mile walt tonight, something i haven't done since the first of the year. i will report back in later on.
good luck all!
last edited: 3/21/07 4:27:50 PM”
“cyndeee - What dose have you been taking?”
“Nine days sounds absolutely smashing, if it works for me.
I read somewhere that you can continue to take Glucosamine with the Celadrin. The two supposedly work together well. I'm also continuing with Naproxen. My knee has been inflamed for the past couple of days and very painful.
Your results sound great Cyndee.
BTW, I got mine in the store under the name ReVivex, in a box that is red on top and lime green (not that kind of lime green) on the bottom. It was in the vitamins and supplements aisle. These are 1500 mg caplets, big enough to choke a horse.”
It works! .. . . . . . . (I hope.)
“Wild Oats did not have it, except in combination with other things. However, a Natural Foods Store had some. The price was reasonable and with a senior discount, it was the same as the Internet shipped price.
So I stopped at the pool hall, where one knee was hurting badly as I limped in. I sat down and ordered a cold one, that is, a bottle of water and a cup of ice. I took one of the soft gels, sat back and read the directions. It said three per day all at once, so I swallowed two more. They are 1,050 mg. each.
I was there for 30-40 minutes. Got to talk a little with an old friend from Baltimore, who stopped in for a few minutes. Then I rose to leave and discovered that my worse knee hardly hurt anymore. It had to be the rest or a fast acting pain killer. We'll see how it goes from here.”
“I have been giving my dog glucosamine the past 3 months with some relief, would this be safe to give to my dog?”
“My knee hurt less today, but I'm not sure if it was the celadrin or whatever I did to my knee is healing. The next few days should reveal something.”
“For HOI and Pamela”
“Thank you Sassafras”
1 month update
“i feel that the celadrin has worked good for me. not a cure but i am doing better than i was. after the first 2 weeks i haven't noticed anymore improvement. i don't limp when i walk and i can kneal at church, but not the entire time. the pain does not keep me awake at night and i can get out of bed in the morning without struggling. but no more improvement. i went for a 3 mile walk a couple of weeks ago and although it was slow coming back i did make it. had some extra pain but it soon went away. i am going to stay on it and i don't use as much naproxen, maybe 1 a day. i'm trying to keep up with the bike riding and the gym but it has been hard with my dad not doing well. they never called me back fro the clinical trial that i signed up for so i called them today and they should call back tomorrow. they will do an iv infusion twice, two weeks apart and then follow me for 6 months. hope i can start soon.”
“It helped me almost immediately. I still have some pain, but only anticipation of real severe pain. Naturally, I move very carefully. There has been no noticeable improvement after the initial jolt. But I don't believe thare was any claim of promoting a cure, just some relief.
I plan to continue with it and expect to purchase some more on Thursday.
last edited: 4/10/07 7:39:08 PM”
“How did I miss this whole thread? OMGosh, I'm going to go look for it tonight. I have an appt in rhumetology next month. I have to say, I'm not impressed with the glucosomine/chondroitin/msm and I've been on it since December. I even went to the trouble of searching on the web for the best recommended brand of it and I'm still having pain. The hips are not bothering me so much as before. I've given up sleeping on my sides completely and only sleep on my belly; kind of difficult to change the way you sleep after this many years.
Does anyone understand this?:
Rheumatoid factor <20 IU/mL”
“No, I don't understand it fully. But I understand pain!
I stopped taking the MSM.”
“I found the Celadrin! I looked at Wal-Mart, but it was not there. I found it at a CVS pharmacy, formerly known as Sav-On. It normally costs $19.99, but they were on sale for $10, so I bought two. It says to take three softgels one to two times daily. I plan to take it twice daily. Should I bother taking the glucosamine anymore?
I so hope that this is the ticket I need. I cannot even begin to imagine giving up backpacking when I have finally gotten to do it; only two years now. I used to have terrible bursitis in both hips and I never could before, but the neurologist put me on Topomax for migraines and somehow this affects how your central nervous system perceives pain, and the pain in my hips went away too.”
“Cyndee and Nowslimmer, Thanks for the reviews!! Glad you two are feeling better.
Pamela, CVS probably bought the Sav-on. They are a canadian company that has been around for ages. They were my first real job (19 years ago).”
“I have a backpack in mid May with the troop, I hope to be able to do it.”
“I'm having bad days and better days with the Celadrin. Still taking glucosamine, but I stopped MSM long ago. I also still need the Naproxin twice a day or pay the price.”
“Yes, I've experienced a mixture of days, too. But I've been able to attribute it to other factors.
My blood pressure was up today, so I now have some more pills to take. Also, I have to have a diabetes test Monday. And my doctor is restricting me from continuing to eat all this Christmas, Valentine's Day and Easter candy! It makes me mad, because I know fatso is eating some of the stuff herself!
This hurts because my need for a sugar fix is almost continuous. As a doctor she is trying hard to keep me alive. That way she gets more money before the undertaker cashes in on me!”
“it's all about the berries nowslimmer, that's how you get your sugar fix! you probably can't have potassium, so forget bananas for a sugar fix or oranges for that matter, i'm not sure about grapes.”
“I go for shredded mini wheats for my sugar rush, and oranges. Shoot, who am I kidding....I only go for that stuff if there isn't any candy in the house.”
“i love cream cheese and strawberries on toast! i was diabetic during my third pregnancy.”
“i find that when exercise is added into the mix i have less pain. duh!!!!!!! i will be doing at least a 20miler this afternoon on the pinellas trail. haven't gotten on the bike in over a week with all the stuff that has been going on. i think i will find a rheumatologist also, and give that a try. i'm glad we are all having some sucess celadrin.”
“I've been watching this thread and decided to try the Celadrin. I got it at CVS last night, for the half price of $10/per bottle, but I also noticed the expiration date was 03/07. I also noticed that each tablet has 20 calories, as it's high in fat - even smells like lanolin.
I've always taken glucosomine and chondrotin, then my doctor said it was the chondrotin that did the trick, and buying only that was cheaper.”
“I noticed the fat thing too, WAHOOOOO MORE CALORIES! I need 'em!!! Mine was 1/2 price too, I don't know how long that will last. I will have to look at the exp. date. I don't think I'm worried about it so much though.”
“I'm not worried about the date or the calories - got to keep my weight up!
“So Cyndee, what do you think of Celdrin now?”
“This thread impressed me. My old dog and I are trying it out, too.”
“Maybe it's kept my knee from getting worse. But I am seeing the same pattern of 6 weeks pain and then it slowly receeds. So I can't say if I feel less pain or not.”
After one month plus.
“I finished my first bottle of Celadrin about a week ago. I had lapsed into a feeling of not knowing if it was helping me or not. Some days were better than others. Sometimes I would forget to take my staff with me from the car into the pool hall. Other days I would take it, either because my knees were hurting, or just to make it a habit. Due to a mishap by the computer, my next bottle of Celadrin, along with some papers and other things had slipped down behind a bookcase. I simply had not felt like digging things out, but yesterday afternoon I finally did it. I took my day's dosage of Celadrin immediately.
Living in a small area with lots of junk, I have a lot of difficulty manuvering in most areas. However, in a short while, after taking the medication following a lapse of a week without it, I discovered that I was manuvering much better. I was not grasping as many things in order to get through the most difficult areas. I had more confidence walking and the pain was not as bad. The same remained true today. So the medication is definitely working for me.
I understand that the medicine will not cure my knees. I just hope that it will be enough to keep me from surgery.
The reason for taking the staff with me is that it is a weapon. I have had some training using it as a weapon. Many people have complimented that is is a good looking staff. Some have recognized that it is a weapon. So I like having it with me to help stabliize my walking, and for protection, in case it is needed. Some would-be assailants, thinking that I might be an easy mark, might avoid me when they see the staff in my hands.
“I'm glad it's working for you nowslimmer, I wish I knew if it were working for me.”
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